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Pig Liver Esterase-catalyzed Hydrolysis of Three Diesters of meso-Bicyclic Dicarboxylic Acid and Three Tetraesters of Tetrahydrofuran-2, 3,4,5-tetracarboxylic Acid
Authors:MA Guang-En  Tamm Ch
Affiliation:1. National Institutes of Pharmaceutical Research & Development, Beijing 102206, P. R. China;
2. Institut fur Organishe Chemie der Universitat Basel, CH-4056 Basel Switzerland
Abstract:Three diesters of exo- syn-meso-oxabicyclo (2, 2, 1 ) -hept- 5- ene- 2, 3- dicarboxylic acid and three tetraesters of tetrahydrofuran-2, 3, 4, 5-tetracarboxylic acid were synthesized and tested with enantioselective hydrolysis catalyzed by pig liver esterase(PLE). The results of the PLEcatalyzed hydrolysis were discussed.
Keywords:Oxabicyclo(2   2   1 )-hept-5-ene-2   3-dicarboxylic acid   Tetrahydrofuran-2   3   4   5- tetracarboxylic acid   Esterification   Hydrolysis    Pig liver esterase(PLE)
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