| 单细胞分析技术研究进展 |
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| 引用本文： | 刘佳,刘震. 单细胞分析技术研究进展[J]. 色谱, 2016, 34(12): 1154-1160. DOI: 10.3724/SP.J.1123.2016.08041 |
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| 作者姓名： | 刘佳 刘震 |
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| 作者单位： | 南京大学化学化工学院, 生命分析化学国家重点实验室, 江苏 南京 210023 |
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| 基金项目： | 国家杰出青-科学基金项目（21425520）；国家重大科研仪器研制项目（21627810）. |
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| 摘 要： | 细胞是生命结构和生命活动的基本单位，基于单细胞的研究是生命研究的基础。由于细胞体积极小、细胞微环境复杂并且起到关键作用的组分含量往往较低，因此在很多方面单细胞分析仍然是一项具有挑战性的任务。该文对现有的单细胞分析技术进行归纳、总结，重点介绍了不同单细胞分析技术的特点及其应用的最新进展。
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| 关 键 词： | 单细胞分析 毛细管电泳 微流控芯片 质谱 综述 |
| 收稿时间： | 2016-08-31 |
Recent advances in single cell analysis technologies |
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| LIU Jia,LIU Zhen. Recent advances in single cell analysis technologies[J]. Chinese journal of chromatography, 2016, 34(12): 1154-1160. DOI: 10.3724/SP.J.1123.2016.08041 |
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| Authors: | LIU Jia LIU Zhen |
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| Affiliation: | School of Chemistry and Chemical Engineering of Nanjing University, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing 210023, China |
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| Abstract: | Cells are the basic units of the structure and activities of living species, and single cell-based research is the foundation of life science researches. Because of the tiny volume of cells, complex microenvironment within cells and the low concentrations of their components, single cell analysis is still a challenging task in many aspects. In this review, we summarize and discuss the recent advances in single cell analysis technologies, and emphasize the characteristics and the state of the applications of different techniques. |
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| Keywords: | single cell analysis capillary electrophoresis (CE) microfluidic chip mass spectrometry (MS) review |
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