Hydrogenative Dearomatization of Pyridine and an Asymmetric Aza‐Friedel–Crafts Alkylation Sequence |
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| Authors: | Shuo‐Guo Wang Prof. Dr. Shu‐Li You |
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| Affiliation: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/ |
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| Abstract: | Highly efficient synthesis of enantiomerically enriched substituted piperidines has been realized via chiral phosphoric acid catalyzed cascade hydrogenative dearomatization of substituted pyridines and aza‐Friedel‐Crafts reaction in good to excellent yields and enantioselectivity. |
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| Keywords: | asymmetric catalysis heterocycles organocatalysis reduction synthetic methods |
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