Synthesis and Structural Characterization of Pyrrole Heterocyclic Systems Bearing Amino Acid Units: Novel Pyrrol‐3‐ones,Pyrrolo[1,2‐a][3,1]benzoxazines,and Pyrrolo[2,1‐b][1,3]oxazoles |
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| Authors: | İrfan Koca Mustafa Saçmacı Filiz Yılmaz Şevket Hakan Üngören |
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| Affiliation: | 1. Department of Chemistry, Faculty of Arts and Sciences, Bozok University, Yozgat, Turkey;2. Department of Chemistry, Faculty of Arts and Sciences, Anadolu University, Eski?ehir, Turkey |
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| Abstract: | Furan‐3‐one derivatives 1 were converted into 2‐hydroxy‐pyrrole‐3‐ones 4 by reacting with various α‐ and β‐amino acids. In contrast, the reaction of furan‐3‐ones and 1‐aminocyclobutanecarboxylic acid afforded spiro‐pyrrolo[2,1‐b][1,3]oxazoles 5 via the pyrrole‐3‐one intermediate under the same reaction conditions. Some of 2‐hydroxy‐pyrrole‐3‐ones 3 derived from anthranilic acids were transformed to pyrrolo[1,2‐a][3,1]benzoxazines via intramolecular esterification. |
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