An Efficient Synthesis of Pyrrolo[1,2‐a]quinazoline Derivatives in Ionic Liquid Catalyzed by Iodine |
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| Authors: | Lian Lu Ke Yang Mei‐Mei Zhang Xiang‐Shan Wang |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou Jiangsu, People's Republic of China;2. The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou Jiangsu, People's Republic of China |
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| Abstract: | A mild, green, and facile method for the synthesis of 2,3,3a,4‐tetrahydropyrrolo[1,2‐a]quinazoline‐1,5‐dione derivatives is described in high yields by using ionic liquids as green media. The method involves the reaction of 2‐aminobenzamides with 4‐oxopentanoic acid or 4‐aryl‐4‐oxo‐butanoic acid catalyzed by iodine and has the advantages of mild reaction conditions, high yields, one‐pot, operational simplicity, and environmentally benign. |
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