Synthesis of Isoindolo[2,1‐a]quinazoline Derivatives in Ionic Liquid Catalyzed by Iodine |
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| Authors: | Lian Lu Ke Yang Mei‐Mei Zhang Xiang‐Shan Wang |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu, China;2. The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou, Jiangsu, China |
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| Abstract: | A mild, green, and facile method for the synthesis of 6,6a‐dihydroisoindolo[2,1‐a]quinazoline‐5,11‐dione derivatives is described in high yields using ionic liquids as green media. The method involves the reaction of 2‐aminobenzamides with 2‐formylbenzoic acid catalyzed by iodine and provides a new alkaloid library with potential activity for biomedical screening. |
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