Copper‐Catalyzed 8‐Amido Chelation‐Induced Remote C−H Amination of Quinolines |
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| Authors: | Harekrishna Sahoo Mallu Kesava Reddy Isai Ramakrishna Dr. Mahiuddin Baidya |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology Madras, Chennai, India |
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| Abstract: | A copper‐catalyzed 8‐amide chelation‐induced remote C?H amination of quinolines has been developed. This direct amination with readily available azodicarboxylates proceeded with perfect C5‐regioselectivity offering amino‐substituted 8‐aminoquinolines, important bioactive molecular scaffolds, in very high yields (up to 96 %). A single‐electron transfer (SET)‐mediated mechanism with kH/kD=1.1 was proposed after trapping of the radical intermediate. |
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| Keywords: | amination azo compounds C− H activation copper homogeneous catalysis |
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