| Structure and Performance Modulation of Self-Adhesive SIS/C5 Electrospun Membranes for Transdermal Drug Delivery北大核心CSCD |
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| 作者姓名： | 刘丰硕 董茜 赵忠夫 刘伟 张春庆 |
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| 作者单位： | 1.大连理工大学化工学院，精细化工国家重点实验室，大连 116024;2.大连理工大学附属肿瘤医院（辽宁省肿瘤医院），沈阳 110042 |
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| 基金项目： | 中央高校基本科研业务费(DTU21YG132);国家自然科学基金项目(51673034) |
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| 摘 要： | Electrospun membranes are widely utilized to enhance the water vapor permeability and drug delivery performance of transdermal drug delivery patches. Due to the lack of adhesion property，however，most of them cannot closely contact with skin，which impedes the delivery of drugs to the skin，thus affecting the transdermal administration. C5 resin is used to endow poly（styrene isoprene styrene）（SIS）electrospun membranes with pressure-sensitive adhesion property. Investigation is performed on how to control the structure，adhesion properties and drug delivery performance of SIS/C5 electrospun membranes loaded with synthetic capsaicin via compositions，drugs and electrospinning conditions. The results demonstrate that the electrospun membrane with a SIS/C5 ratio of 2∶1 has excellent water vapor permeability（7. 17×10－3 g/（h·cm2）and adhesion properties（180（°）peel strength is 0. 2 kN/m，tack force is 0. 64 N/cm2 ，holding power is greater than 7 days）. The synthetic capsaicin has good compatibility with the SIS/C5 electrospun membranes，in which no drug crystallizes and the drug loading is beneficial to improve the water vapor permeability. As the drug loading is 8%，the tack force is 0. 6～0. 8 N/cm2 ，the 180（°）peel strength is 0. 2～0. 3 kN/m，the holding power is greater than 7 days，and no residue is left during peeling tests. In vitro drug release indicates that the drug has a behavior of sustained release with a 24-hour cumulative release rate of greater than 50% for all SIS/ C5 electrospun membranes，meeting the requirements of transdermal drug delivery patches. © 2022, Science Press (China). All rights reserved.
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| 关 键 词： | 外用贴剂 静电纺丝 自黏性 药物缓释 |
| 收稿时间： | 2021-12-02 |
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