A Ruthenium Based Organometallic Complex for Biosensing that is both a Stable Redox Label and a Homobifunctional Linker |
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| Authors: | Yeng Ying Lee Stephen G. Parker Abbas Barfidokht Muhammad Tanzirul Alam D. Barney Walker Barbara A. Messerle J. Justin Gooding |
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| Affiliation: | 1. School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia;2. Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW 2052, Australia |
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| Abstract: | A stable ruthenium‐based redox label, Ru(acetylacetonate)2(bipyridine‐NH2), has been synthesized with the target of circumventing the problem associated with the use of ferrocene for biosensing in solutions containing chloride ions. The redox species was shown to be highly stable with repeated cycling in biological buffers as well as being amenable to surface coupling reactions. To demonstrate the latter, the redox label was anchored onto a self‐assembled monolayer of 6‐mercaptohexanoic acid, using carbodiimide coupling, followed by binding of a pentapeptide to the redox label. |
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| Keywords: | Redox label Ruthenium complex Ferrocene Self‐assembled monolayer Biosensor |
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