Dually Electroactive Disulfide‐Confined Aryldiazonium Salt Used as a Linker Molecule for Preparing Immunosensor Platforms |
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| Authors: | Md. Mohibul Islam Khan Mithrabinda K. Poduval Tae‐Hyun Kim Kyuwon Kim |
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| Affiliation: | Department of Chemistry, Incheon National University, Incheon 406–772, Korea |
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| Abstract: | A new electroactive disulfide‐confined aryl diazonium (DSAD) salt was synthesized and used as a linker for biomolecules immobilization to prepare two kinds of immunoassay platforms. DSAD was electrodeposited on ITO electrode surfaces by cyclic voltammetry. Disulfide group of DSAD attached on the surfaces were electrochemically oxidized into thiosulfinate or thiosulfonate groups. For the first work, a detection of rabbit antigen was performed on ITO microelectrodes array by spatially‐selective approach. In the second work, DSAD was deposited on electrochemically reduced graphene oxide‐modified ITO surfaces, which were used as a platform for electrochemical sandwich immunoassay for detecting mouse antigen. |
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| Keywords: | Diazonium salt Graphene Electrodeposition Microelectrode array Immunoassay |
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