Multiwalled Carbon Nanotubes‐Chitosan Modified Single‐Use Biosensors for Electrochemical Monitoring of Drug‐DNA Interactions |
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| Authors: | Ceren Sengiz Gulsah Congur Ece Eksin Arzum Erdem |
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| Affiliation: | 1. Ege University, Faculty of Pharmacy, Analytical Chemistry Department, 35100, Bornova, Izmir, Turkey tel: +90?232?311?51?31;2. fax: +902323885258;3. Ege University, Graduate School of Natural and Applied Science, Material Science and Engineering Department, 35100, Bornova, Izmir, Turkey;4. Ege University, Graduate School of Natural and Applied Science, Biotechnology Department, 35100, Bornova, Izmir, Turkey |
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| Abstract: | A multiwalled carbon nanotubes (CNT)‐chitosan (CHIT) modified pencil graphite electrode (CNT‐CHIT/PGE) was developed for the first time herein for electrochemical monitoring of the interaction of an anticancer drug, mitomycin C (MC) and DNA. The characterization of unmodified PGE, CHIT/PGE, CNT/PGE and CHIT‐CNT/PGE were performed by scanning electron microscopy and cyclic voltammetry techniques. The oxidation signals of MC and guanine were measured before and after interaction at the surface of CNT‐CHIT/PGEs using differential pulse voltammetry. Electrochemical impedance spectroscopy technique was also successfully utilized for monitoring of the interaction process at the surface of CNT‐CHIT/PGEs in different interaction times. |
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| Keywords: | Multiwalled carbon nanotubes Chitosan Drug‐DNA interactions Electrochemical biosensors Mitomycin C |
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