| 塑料芯片毛细管电泳电化学检测系统及其性能评价 |
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| 引用本文： | 陈志锋,高云华,李成武,林金明. 塑料芯片毛细管电泳电化学检测系统及其性能评价[J]. 高等学校化学学报, 2004, 25(12): 2253-2255 |
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| 作者姓名： | 陈志锋 高云华 李成武 林金明 |
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| 作者单位： | 1. 中国科学院理化技术研究所, 北京100101;2. 中国科学院生态环境研究中心, 北京100085 |
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| 基金项目： | 国家高技术研究发展计划项目 (批准号 :2 0 0 1AA63 0 5 0 3 )，国家自然科学基金 (批准号 :2 0 2 75 0 42 )，中国科学院“百人计划”项目资助 |
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| 摘 要： | 近年来，高分子芯片毛细管电泳技术发展迅速，以聚甲基丙烯酸甲酯(PMMA)为代表的塑料电泳芯片由于其低廉的制作成本与良好的电渗性能，已经成为芯片电泳技术发展的一个重要方向，电化学检测具有灵敏度高、选择性好和易于微型化等优点，因此在塑料芯片电泳领域中具有较好的应用前景。
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| 关 键 词： | 聚甲基丙烯酸甲酯 毛细管电泳芯片 电化学检测 微盘电极 |
| 文章编号： | 0251-0790(2004)12-2253-03 |
| 收稿时间： | 2003-09-06 |
Configuration and Property Evaluation of a Novel Plastic Capillary Electrophoresis Microchip with Electrochemical Detection System |
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| CHEN Zhi-Feng ,GAO Yun-Hua ,LI Cheng-Wu ,LIN Jin-Ming. Configuration and Property Evaluation of a Novel Plastic Capillary Electrophoresis Microchip with Electrochemical Detection System[J]. Chemical Research In Chinese Universities, 2004, 25(12): 2253-2255 |
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| Authors: | CHEN Zhi-Feng GAO Yun-Hua LI Cheng-Wu LIN Jin-Ming |
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| Affiliation: | 1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101, China;2. Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100058, China |
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| Abstract: | A poly(methyl methacrylate)-based capillary electrophoresis microchip, integrated with a microelectrode-based end-column amperometric detection, was described. A short unclosed portion of the separation channel from the detection cell was used as a working-electrode guide channel. With the aid of a three-dimension micropositioner and an optical microscope, a home-made 6 μm carbon-fiber microdisk electrode(tip diameter of 20 μm) was positioned along the guide channel at 30 μm distance from the channel outlet. With dopamine and catechol the as model analytes, the analytical performance of the system was demonstrated and the detection limit of 1.6×10-7mol/L for dopamine was achieved, to our knowledge, which is the lowest value than that from published literatures using electrophoresis microchip with end-column amperometric detection. |
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| Keywords: | Poly(methyl methacrylate) Capillary electrophoresis microchip Electrochemical detection Microdisk electrode |
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