A mathematical model of a P53 oscillation network triggered by DNA damage |
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| Authors: | Xia Jun-Feng and Jia Ya |
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| Affiliation: | Department of Physics and Institute of Biophysics, Central China Normal University, Wuhan 430079, China |
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| Abstract: | Taking the interaction between a DNA damage repair module, an ATMmodule, and a P53--MDM2 oscillation module into account, this paperpresents a mathematical model of a P53 oscillation network triggeredby a DNA damage signal in individual cells. The effects of the DNAdamage signal and the delay time of P53-induced MDM2 expression onthe behaviours of the P53 oscillation network are studied. In theoscillatory state of the P53--MDM2 oscillator, it is found that thepulse number of P53--P oscillation increases with the increase of theinitial DNA damage signal, whereas the amplitude and the period ofP53--P oscillation are fixed for different initial DNA damagesignals, and the period numbers of P53--P oscillations decreasewith the increase of time delay of MDM2 expression induced by P53.These theoretical predictions are consistent with previousexperimental results. The combined negative feedback of P53--MDM2with the time delay of P53-induced MDM2 expression causes oscillationbehaviour in the P53 network. |
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| Keywords: | P53 oscillation network DNA damage signal time delay kinetic model |
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