Total Synthesis of Proposed Structure of Yuremamine and All Diastereomers Using [3+2]‐Cycloaddition of Platinum‐Containing Azomethine Ylide |
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| Authors: | Tomoya Ohyama Masako Uchida Prof.Dr. Hiroyuki Kusama Prof. Dr. Nobuharu Iwasawa |
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| Affiliation: | 1. Department of Chemistry, Tokyo Institute of Technology, Tokyo, Japan;2. Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan |
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| Abstract: | Total synthesis of the proposed structure of yuremamine has been achieved for the first time based on the intermolecular [3+2]‐cycloaddition reaction of the platinum‐containing azomethine ylide. All the possible diastereomers of yuremamine were also synthesized via the common intermediate. Through these syntheses, it was confirmed that the proposed structure of yuremamine and the diastereomers differ from the natural product. |
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| Keywords: | [3+2] cycloaddition azomethine ylide platinum total synthesis yuremamine |
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