Lewis base‐catalyzed electrophilic lactonization of selenyl bromide resin and facile solid‐phase synthesis of furan‐2(5H)‐one derivatives |
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| Authors: | Rong Jun He Bing Chun Zhu Yu Guang Wang |
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| Affiliation: | 1. College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, People's Republic of China;2. Zhejiang Research Institute of Chemical Industry, Hangzhou, Zhejiang, People's Republic of China |
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| Abstract: | A facile solid‐phase synthesis approach was developed for the rapid synthesis of multi‐substituted furan‐2(5H)‐one derivatives libraries. The synthetic strategy included the selenyl bromide resin‐induced electrophilic lactonization catalyzed by Lewis base, lithiation, nucleophilic substitution and oxidation–elimination of the selenium resins. The advantages of the new method are good yields, high purity, straightforward operations and high diversity of the products, lack of odor, and good stability of the selenium resins. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | electrophilic lactonization Lewis base selenium resins solid‐phase synthesis furan‐2(5H)‐one derivatives library |
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