Core‐shell structure microcapsules with dual pH‐responsive drug release function |
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| Authors: | Chih‐Hui Yang Chih‐Yu Wang Alexandru Mihai Grumezescu Andrew H.‐J. Wang Ching‐Ju Hsiao Zu‐Yu Chen Keng‐Shiang Huang |
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| Affiliation: | 1. Department of Biological Science and Technology, I‐Shou University, Kaohsiung, Taiwan;2. Department of Biomedical Engineering, I‐Shou University, Kaohsiung, Taiwan;3. Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania;4. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan;5. The School of Chinese Medicine for Post‐Baccalaureate, I‐Shou University, Kaohsiung, Taiwan |
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| Abstract: | We report dual pH‐responsive microcapsules manufactured by combining electrostatic droplets (ESD) and microfluidic droplets (MFD) techniques to produce monodisperse core (alginate)‐shell (chitosan) structure with dual pH‐responsive drug release function. The fabricated core‐shell microcapsules were size controllable by tuning the synthesis parameters of the ESD and MFD systems, and were responsive in both acidic and alkaline environment, We used two model drugs (ampicillin loaded in the chitosan shell and diclofenac loaded in the alginate core) for drug delivery study. The results show that core‐shell structure microcapsules have better drug release efficiency than respective core or shell particles. A biocompatibility test showed that the core‐shell structure microcapsules presented positive cell viability (above 80%) when evaluated by the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. The results indicate that the synthesized core‐shell microcapsules were a potential candidate of dual‐drug carriers. |
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| Keywords: | Core‐shell Drug carriers Drug release Dual pH‐responsive |
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