Metal‐Free Decarboxylative Cyclization/Ring Expansion: Construction of Five‐, Six‐, and Seven‐Membered Heterocycles from 2‐Alkynyl Benzaldehydes and Cyclic Amino Acids |
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| Authors: | Srinivas Samala Gajendra Singh Ravi Kumar Dr. Ravi Sankar Ampapathi Dr. Bijoy Kundu |
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| Affiliation: | 1. Medicinal and Process Chemistry Division, CSIR‐Central Drug Research Institute, Lucknow, 226031 (India);2. NMR Division, Sophisticated and Analytical Instrument Facility, CSIR‐Central Drug Research Institute, Lucknow, 226031 (India);3. Academy of Scientific and Innovative Research, New Delhi‐110001 (India) |
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| Abstract: | A one pot synthesis of 1H‐benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1,2‐b]azepines from 2‐alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one C? N and two C? C bonds) by a metal‐free decarboxylation/cyclization/one‐carbon ring expansion sequence in one pot. |
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| Keywords: | amino acids azomethine ylides heterocycles ring expansion synthetic methods |
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