Rhodium(II)‐Catalyzed Cycloaddition Reactions of Non‐classical 1,5‐Dipoles for the Formation of Eight‐Membered Heterocycles |
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| Authors: | Dong Jin Lee Donguk Ko Prof. Eun Jeong Yoo |
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| Affiliation: | Department of Chemistry, Kangwon National University, 1 Kangwondaehak‐gil, Chuncheon, 200‐701 (Republic of Korea) |
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| Abstract: | A new type of intermolecular rhodium(II)‐catalyzed [5+3] cycloaddition has been developed. This higher‐order cycloaddition between pyridinium zwitterion 1,5‐dipole equivalents and enol diazoacetates enables the formation of eight‐membered heterocyclic skeletons, which are otherwise difficult to construct. The optimized cycloaddition occurs efficiently under mild conditions with a wide range of pyridinium zwitterions and with high functional‐group tolerance. |
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| Keywords: | cycloaddition eight‐membered heterocycles homogeneous catalysis rhodium zwitterions |
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