Near‐Infrared‐Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy |
| |
| Authors: | Jingxin Shao Mingjun Xuan Dr. Luru Dai Dr. Tieyan Si Prof. Junbai Li Prof. Qiang He |
| |
| Affiliation: | 1. Key Lab for Microsystems and Microstructures Manufacturing, Micro/Nanotechnology Research Center, Harbin Institute of Technology, Yikuangjie 2, Harbin 150080 (China);2. Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beiyitiao 11, ZhongGuanCun, Beijing 100190 (China);3. Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beiyijie 2, ZhongGuanCun, Beijing 100190 (China) |
| |
| Abstract: | Photothermal therapy based on gold nanostructures has been widely investigated as a state‐of‐the‐art noninvasive therapy approach. Because single nanoparticles cannot harvest sufficient energy, self‐assemblies of small plasmonic particles into large aggregates are required for enhanced photothermal performance. Self‐assembled gold nanorods in lipid bilayer‐modified microcapsules are shown to localize at tumor sites, generate vapor bubbles under near‐infrared light exposure, and subsequently damage tumor tissues. The polyelectrolyte multilayer enables dense packing of gold nanorods during the assembly process, which leads to the formation of vapor bubbles around the excited capsules. The resulting vapor bubbles achieve a high efficiency of suppressing tumor growth compared to single gold nanorods. In vivo experiments demonstrated the ability of soft‐polymer multilayer microcapsules to cross the biological barriers of the body and localize at target tissues. |
| |
| Keywords: | gold nanorods layer‐by‐layer microcapsules photothermal therapy vapor bubbles |
|
|
