| 三氟甲基磺酸锌催化选择性合成2-苄基-4-氯苯酚 |
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| 引用本文： | 马忠华,张佳燕,聂进. 三氟甲基磺酸锌催化选择性合成2-苄基-4-氯苯酚[J]. 应用化学, 2010, 27(3): 304-307. DOI: 10.3724/SP.J.1095.2010.90271 |
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| 作者姓名： | 马忠华 张佳燕 聂进 |
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| 作者单位： | (1.华中科技大学化学与化工学院 武汉 430074；2.华中农业大学理学院化学系 武汉) |
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| 摘 要： | 在温和条件下，Zn(OTf)2能有效催化氯化苄对对氯苯酚的C-苄基化反应，选择性合成杀菌剂2-苄基-4-氯苯酚（BCP），合成的优化条件为n(对氯苯酚):n(氯化苄)=1.2:1，催化剂Zn(OTf)2对氯化苄摩尔分数为5%，60 ℃下反应6 h，用硝基甲烷为溶剂，氯化苄转化率和产物BCP的产率分别＞99%和94%。
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| 关 键 词： | Zn(OTf)2，苄基氯苯酚，付-克氏烷基化反应，对氯苯酚，氯化苄 |
| 收稿时间： | 2009-04-14 |
| 修稿时间： | 2009-07-23 |
Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)_2 |
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| MA Zhong-Hua,ZHANG Jia-Yan,NIE Jin. Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)_2[J]. Chinese Journal of Applied Chemistry, 2010, 27(3): 304-307. DOI: 10.3724/SP.J.1095.2010.90271 |
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| Authors: | MA Zhong-Hua ZHANG Jia-Yan NIE Jin |
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| Affiliation: | (1.School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan 430074;2.Department of Chemistry,College of Basic Sciences,Huazhong Agricultural University,Wuhan) |
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| Abstract: | C-Benzylation of 4-chlorophenol(BCP) was selectively perpared via the catalysis of Zn(OTf)_2 under mild conditions with an excellent yield. The optimum reaction conditions included that the molar ratio of the reactants (4-chlorophol:benzyl chloride) was 1.2:1,5% Zn(OTf)_2(molar ratio),and 6 h agitation at 60 ℃ in nitromethane. The conversion of 4-chlorophenol and selectivity of BCP were ＞99% and 94%,respectively under the conditions. |
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| Keywords: | Zn(OTf)_2 benzyl-chlorophenol Friedel-Crafts alkylation p-chlorophenol benzyl chloride |
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