| 含乳糖聚电解质靶向微胶囊的层层自组装构筑 |
| |
| 引用本文： | 高遐,张馥,陈志春,林贤福. 含乳糖聚电解质靶向微胶囊的层层自组装构筑[J]. 高等学校化学学报, 2011, 32(4): 957-963 |
| |
| 作者姓名： | 高遐 张馥 陈志春 林贤福 |
| |
| 作者单位： | 浙江大学化学系, 杭州 310027 |
| |
| 基金项目： | 国家自然科学基金(批准号:20874086)资助 |
| |
| 摘 要： | 设计合成了己二酸乳糖乙烯酯/对苯乙烯磺酸钠共聚物（PLESS），通过层层自组装技术构筑聚烯丙基胺盐酸盐（PAH）与含乳糖聚电解质PLESS的靶向微胶囊。以紫外-可见吸收光谱监测了PAH与PLESS在平面的石英片进行层层自组装过程，研究了不同实验条件（聚电解质浓度、溶液盐度、盐种类）对PAH/PLESS多层膜自组装的影响；PAH与PLESS在球形碳酸钙微球模板上层层自组装，去除模板后得到层状结构的微胶囊，用透射电镜（TEM）等方法观察其形态形貌；通过花生凝集素识别考察其潜在靶向性；通过细胞MTT活性试验评价其生物相容性。
|
| 关 键 词： | 乳糖 层层自组装 微胶囊 肝靶向性 生物相容性 |
| 收稿时间： | 2010-07-23 |
Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte |
| |
| GAO Xia,ZHANG Fu,CHEN Zhi-Chun,LIN Xian-Fu. Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte[J]. Chemical Research In Chinese Universities, 2011, 32(4): 957-963 |
| |
| Authors: | GAO Xia ZHANG Fu CHEN Zhi-Chun LIN Xian-Fu |
| |
| Affiliation: | Department of Chemistry, Zhejiang University, Hangzhou 310027, China |
| |
| Abstract: | Hepatic-targeting microcapsules were constructed by layer-by-layer(LBL) self-assembly of poly(allylamine hydrochloride)(PAH) and chemo-enzymatic synthesized poly(vinyl lactose ester-co-sodium p-styrenesulfonate)(PLESS) containing lactose branches.Alternate deposition of PAH and PLESS was carried out on different solid surfaces such as quartz slides and CaCO3 microparticles.The self-assembly nature of the novel polyelectrolytes was investigated in detail by varying polyelectrolytes concentration,ionic streng... |
| |
| Keywords: | Lactose Layer-by-layer self-assembly Microcapsule Hepatic targeting Biocompatibility |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
|
点击此处可从《高等学校化学学报》下载全文 |
