Construction of Quaternary Stereocenters by Nickel‐Catalyzed Heck Cyclization Reactions |
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| Authors: | Dr. Jean‐Nicolas Desrosiers Liana Hie Dr. Soumik Biswas Dr. Olga V. Zatolochnaya Dr. Sonia Rodriguez Dr. Heewon Lee Dr. Nelu Grinberg Dr. Nizar Haddad Dr. Nathan K. Yee Prof. Neil K. Garg Dr. Chris H. Senanayake |
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| Affiliation: | 1. Department of Chemical Development US, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA;2. http://garg.chem.ucla.edu;3. Department of Chemistry and Biochemistry, University of California, Los Angeles, USA |
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| Abstract: | A nickel‐catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3‐disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active molecules. The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means to construct stereochemically complex frameworks by nonprecious‐metal catalysis. |
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| Keywords: | cyclization Heck reaction heterocycles homogeneous catalysis nickel |
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