Polymeric 1H MRI Probes for Visualizing Tumor In Vivo |
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| Authors: | Prof. Teruyuki Kondo Yu Kimura Hisatsugu Yamada Yasuhiro Aoyama |
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| Affiliation: | 1. Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, JAPAN;2. Research and Educational Unit of Leaders for Integrated Medical Systems, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Katsura, Nishikyo-ku, Kyoto, JAPAN;3. Field of Bioresource Chemistry and Technology, Graduate School of Bioscience and Bioindustry, Tokushima University, 2-1, Minamijosanjima-cho, Tokushima, JAPAN;4. Professor emeritus, Kyoto University, Katsura, Nishikyo-ku, Kyoto, JAPAN |
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| Abstract: | Magnetic resonance imaging (MRI) has become a prominent non– or low–invasive imaging technique, providing high–resolution, three–dimensional images as well as physiological information about tissues. Low–molecular–weight Gd–MRI contrast agents (CAs), such as Gd–DTPA (DTPA: diethylenetriaminepentaacetic acid), are commonly used in the clinical diagnosis, while macromolecular Gd–MRI CAs have several advantages over low–molecular–weight Gd–MRI CAs, which help minimize the dose of CAs and the risk of side effects. Accordingly, we developed chiral dendrimer Gd–MRI CAs, which showed high r1 values. The association constant values (Ka) of S–isomeric dendrimer CAs to bovine serum albumin (BSA) were higher than those of R–isomeric dendrimer CAs. Besides, based on a totally new concept, we developed 13C/15N–enriched multiple–resonance NMR/MRI probes, which realized highly selective observation of the probes and analysis of metabolic reactions of interest. This account summarizes our recent study on developing both chiral dendrimer Gd–MRI CAs, and self–traceable 13C/15N–enriched phosphorylcholine polymer probes for early detection of tumors. |
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| Keywords: | MRI contrast agent dendrimer multiple resonance phosphorylcholine |
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