Convenient One‐Pot Room Temperature Synthesis of 2‐(trifluoromethyl)‐1,2,3,4,7,8‐hexahydroquinolin‐5(6H)‐one derivatives via Catalyst‐Free Multicomponent Reactions |
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| Authors: | Rong Liang‐Ce Shimin Tao Yunyun Zha Sheng Xia Yanian Gao Ming Chen |
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| Affiliation: | College of Chemistry and Chemical Engineering, Key Laboratory of Biotechnology for Medicinal Plant, Jiangsu Normal University, Xuzhou, Jiangsu, People's Republic of China |
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| Abstract: | This paper describes an efficient approach for the synthesis of 2‐(trifluoromethyl)‐1,2,3,4,7,8‐hexahydroquinolin‐5(6H)‐one derivatives via a one‐pot four‐component reaction of aromatic aldehyde, 5,5‐dimethylcyclohexane‐1,3‐dione, 4,4,4‐trifluoro‐1‐(thien‐2‐yl)butane‐1,3‐dione, and NH4OAc with excellent yields at room temperature. In this synthesis, the trifluoromethyl was efficiently introduced in hexahydroquinoline structure, and they may be valuable the drug candidates. This approach also offered several other advantages, such as catalyst‐free, mild conditions, and simple experimental operation. |
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