| 新型手性固定相的合成及其应用 |
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| 引用本文： | 詹正云,周良模. 新型手性固定相的合成及其应用[J]. 化学学报, 1990, 48(11): 1127-1130 |
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| 作者姓名： | 詹正云 周良模 |
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| 作者单位： | 中国科学院大连化学物理研究所 |
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| 摘 要： | 本文采用了一种新的简便方法合成了四个新型手性固定相; N-十一碳-10-烯酰-L-缬氨酸-S-α-苯乙胺(手性-S-1)N-十一碳-10烯酰-L-缬氨酰-R-α-苯乙胺(手性-R-1)及生-S-α, 手性-S-3, 并对外消旋的α-β-氨基酸, 外消旋的α-β-羟基酸和含手性烃基的外消旋胺的进行了折分, 在四丁固定相中手性-S-1对上述对映体的折分选择性最好。
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| 关 键 词： | 氨基酸 苯乙胺P 胺 固定相 羟基羧酸 烯烃P 缬氨酸 十一碳化合物 消旋体拆分 酰化合物 |
Syntheses and their applications of some novel chiral stationary |
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| ZHAN ZHENGYUN,ZHOU LIANGMO. Syntheses and their applications of some novel chiral stationary[J]. Acta Chimica Sinica, 1990, 48(11): 1127-1130 |
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| Authors: | ZHAN ZHENGYUN ZHOU LIANGMO |
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| Abstract: | Four novel chiral stationary phases, N-undecenoyl-L-valyl-S(or R)-a-phenylethylamide(CSP-S-1 or CSP-R-1), N-pentadecyl-L-valyl-S-a-phenylethylamide (CSP-S-2) and N-octadecyl-L-valyl-S-a-phenylethylamide(CSP-S-3) were synthesized by a simple new method. Some racemic a- and b-amino acids, a- and b-hydroxy acids and amines with asym. alkyl group were resolved. The enantioselectivity of CSP-S-1 is the best one for their sepns. |
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| Keywords: | AMINO ACID PHENYLETHYLAMINE P AMINES STATIONARY PHASE HYDROXYCARBOXYLIC ACIDS ALKENE P VALINE C11 COMPOUNDS MESOTOMY ACYL COMPOUND |
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