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α‐Arylation/Heteroarylation of Chiral α‐Aminomethyltrifluoroborates by Synergistic Iridium Photoredox/Nickel Cross‐Coupling Catalysis |
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| Authors: | Dr. Mirna El Khatib Dr. Ricardo Augusto Massarico Serafim Prof. Gary A. Molander |
| Affiliation: | 1. Department of Chemistry, University of Pennsylvania, Roy and Diana Vagelos Laboratories, 231 S. 34th St., Philadelphia, PA 19104‐6323 (USA);2. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S?o Paulo—FCF/USP (Brazil) |
| Abstract: | Direct access to complex, enantiopure benzylamine architectures using a synergistic iridium photoredox/nickel cross‐coupling dual catalysis strategy has been developed. New C(sp3)? C(sp2) bonds are forged starting from abundant and inexpensive natural amino acids. |
| Keywords: | amino acids cross‐coupling heterocycles nickel photochemistry |