Hyperpolarized NMR Spectroscopy: d‐DNP,PHIP, and SABRE Techniques |
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| Authors: | Dr. Kirill V. Kovtunov Ekaterina V. Pokochueva Oleg G. Salnikov Dr. Samuel F. Cousin Dr. Dennis Kurzbach Dr. Basile Vuichoud Prof. Sami Jannin Prof. Eduard Y. Chekmenev Prof. Boyd M. Goodson Dr. Danila A. Barskiy Prof. Igor V. Koptyug |
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| Affiliation: | 1. Laboratory of Magnetic Resonance Microimaging, International Tomography Center, Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk, Russia;2. Novosibirsk State University, Novosibirsk, Russia;3. Université de Lyon, CNRS, Université Claude Bernard Lyon?1, école normale supérieure de Lyon (ENS de Lyon), Institut des Sciences Analytiques, UMR?5280, Villeurbanne, France;4. Laboratoire des biomolécules, LBM, Département de chimie, école normale supérieure, PSL University, Sorbonne Université, CNRS, Paris, France;5. Department of Chemistry, Integrative Biosciences (Ibio) and, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States;6. Russian Academy of Sciences, Moscow, Russia;7. Department of Chemistry & Biochemistry, Materials Technology Center, Southern Illinois University, Carbondale, IL, United States;8. Department of Chemistry, University of California at Berkeley, Berkeley, CA, United States |
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| Abstract: | The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules. Such approaches can overcome the main sensitivity challenges facing modern NMR/magnetic resonance imaging (MRI) techniques, whilst hyperpolarized fluids can also be used in a variety of applications in material science and biomedicine. This Focus Review considers the fundamentals of the preparation of hyperpolarized liquids and gases by using dissolution dynamic nuclear polarization (d‐DNP) and parahydrogen‐based techniques, such as signal amplification by reversible exchange (SABRE) and parahydrogen‐induced polarization (PHIP), in both heterogeneous and homogeneous processes. The various new aspects in the formation and utilization of hyperpolarized fluids, along with the possibility of observing NMR signal enhancement, are described. |
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| Keywords: | biological activity contrast agents hyperpolarization imaging agents NMR spectroscopy |
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