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Triphenylamine‐Appended Half‐Sandwich Iridium(III) Complexes and Their Biological Applications |
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| Authors: | Xiangdong He Meng Tian Dr. Xicheng Liu Yanhua Tang Chang Fang Shao Peiwei Gong Jinfeng Liu Shumiao Zhang Lihua Guo Prof. Zhe Liu |
| Affiliation: | 1. Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, China;2. Qufu Normal University, School of Life Science, Qufu, China |
| Abstract: | Organometallic half‐sandwich IrIII complexes of the type [(η5‐Cpx)Ir(N^N)Cl]PF6 (Cpx: Cp* or its phenyl Cpxph or biphenyl Cpxbiph derivatives; N^N: triphenylamine (TPA)‐substituted bipyridyl ligand groups) were synthesized and characterized. The complexes showed excellent bovine serum albumin (BSA) and DNA binding properties and were able to oxidize NADH to NAD+ (NAD=nicotinamide adenine dinucleotide) efficiently. The complexes induced apoptosis effectively and led to the emergence of reactive oxygen species (ROS) in cells. All complexes showed potent cytotoxicity with IC50 values ranging from 1.5 to 7.1 μm toward A549 human lung cancer cells after 24 hours of drug exposure, which is up to 14 times more potent than cisplatin under the same conditions. |
| Keywords: | apoptosis cancer DNA iridium sandwich complexes |