Basic Physicochemical Properties of Polyethylene Glycol Coated Gold Nanoparticles that Determine Their Interaction with Cells |
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| Authors: | Dr. Pablo del Pino Fang Yang Dr. Beatriz Pelaz Dr. Qian Zhang Karsten Kantner Raimo Hartmann Dr. Natalia Martinez de Baroja Marta Gallego Marco Möller Dr. Bella B. Manshian Dr. Stefaan J. Soenen René Riedel Prof. Dr. Norbert Hampp Prof. Dr. Wolfgang J. Parak |
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| Affiliation: | 1. Fachbereich Physik, Philipps Universit?t Marburg, Marburg, Germany;2. CIC biomaGUNE, San Sebastian, Spain;3. Fachbereich Chemie, Philipps Universit?t Marburg, Marburg, Germany;4. Radiology Department, KULeuven Campus Gasthuisberg, Leuven, Belgium |
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| Abstract: | A homologous nanoparticle library was synthesized in which gold nanoparticles were coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the thickness of the shell of polyethylene glycol, was varied. Basic physicochemical parameters of this two‐dimensional nanoparticle library, such as size, ζ‐potential, hydrophilicity, elasticity, and catalytic activity ,were determined. Cell uptake of selected nanoparticles with equal size yet varying thickness of the polymer shell and their effect on basic structural and functional cell parameters was determined. Data indicates that thinner, more hydrophilic coatings, combined with the partial functionalization with quaternary ammonium cations, result in a more efficient uptake, which relates to significant effects on structural and functional cell parameters. |
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| Keywords: | gold nanoparticles nanoparticle uptake physicochemical properties polyethylene glycol toxicity |
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