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Generalizing the Concept of Specific Compound Formulation Additives towards Non‐Fluorescent Drugs: A Solubilization Study on Potential Anti‐Alzheimer‐Active Small‐Molecule Compounds
Authors:Carmen Lawatscheck  Dr. Marcus Pickhardt  Sebastian Wieczorek  Dr. Andrea Grafmüller  Prof. Dr. Eckhard Mandelkow  Prof. Dr. Hans G. Börner
Affiliation:1. Humboldt-Universit?t zu Berlin, Department of Chemistry, Berlin, Germany;2. German Center for Neurodegenerative Diseases (DZNE), CAESAR Research Center, Bonn, Germany;3. Max Planck Institute of Colloids and Interfaces, Department of Theory and Biosystems, Potsdam, Germany;4. MPI for Metabolism Research, Hamburg Outstation, c/o DESY, Hamburg, Germany
Abstract:Tailor‐made compound formulation additives enable the testing of potential drugs with undesirable pharmacological profiles. A combinatorial approach using Raman microscopy as the readout method is presented to select peptide sequences from large one‐bead‐one‐compound libraries. The resulting peptide–PEG conjugates solubilize potential prophylactic and therapeutic anti‐Alzheimer compounds and can be used as specific additives not only for fluorescent but also for non‐fluorescent compounds.
Keywords:Alzheimer's disease  bioconjugates  combinatorial screening  precision polymers  Tau protein
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