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Bioactive,Elastic, and Biodegradable Emulsion Electrospun DegraPol Tube Delivering PDGF‐BB for Tendon Rupture Repair
Authors:Olivera Evrova  Joanna Houska  Manfred Welti  Eliana Bonavoglia  Maurizio Calcagni  Pietro Giovanoli  Viola Vogel  Johanna Buschmann
Affiliation:1. Division of Plastic Surgery and Hand Surgery, University Hospital Zürich, Zürich, Switzerland;2. Laboratory of Applied Mechanobiology, ETH Zürich, Zürich, Switzerland;3. ab medica, Cerro Maggiore (Milan), Italy
Abstract:Healing of tendon ruptures represents a major challenge in musculoskeletal injuries and combinations of biomaterials with biological factors are suggested as viable option for improved healing. The standard approach of repair by conventional suture leads to incomplete healing or rerupture. Here, a new elastic type of DegraPol® (DP), a polyester urethane, is explored as a delivery device for platelet‐derived growth factor—BB (PDGF‐BB) to promote tendon healing. Using emulsion electrospinning as an easy method for incorporation of biomolecules within polymers, DegraPol® supports loading and release of PDGF‐BB. Morphological, mechanical and delivery device properties of the bioactive DP scaffolds, as well as differences arising due to different electrospinning parameters are studied. Emulsion electrospun DP scaffolds result in thinner fibers than pure DP scaffolds and experience decreased strain at break [%], but high enough for successful surgeon handling. PDGF‐BB is released in a sustained manner from emulsion electrospun DP, but not completely, with still large amount of it being inside the polymeric fibers after 30 d. In vitro studies show that the bioactive scaffolds promote tenocyte proliferation in serum free and serum+ conditions, demonstrating the potential of this surgeon‐friendly bioactive delivery device to be used for tendon repair.
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Keywords:block copolymers  drug delivery systems  emulsion electrospining  PDGF‐BB release  rabbit tenocytes
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