Visible‐Light‐Mediated Photocatalytic Difunctionalization of Olefins by Radical Acylarylation and Tandem Acylation/Semipinacol Rearrangement |
| |
| Authors: | Dr. Giulia Bergonzini Dr. Carlo Cassani Haldor Lorimer‐Olsson Johanna Hörberg Dr. Carl‐Johan Wallentin |
| |
| Affiliation: | Department of Chemistry and Molecular Biology, Gothenburg University, Gothenburg, Sweden |
| |
| Abstract: | A novel method for the mild photoredox‐mediated tandem radical acylarylation and tandem acylation/semipinacol rearrangement has been developed. The synthesis of highly functionalized ketones bearing all‐carbon α‐ or β‐quaternary centers has been achieved using easily available symmetric aromatic carboxylic anhydrides as the acyl radical source. The method allows for a straightforward introduction of the keto functionality and concomitant construction of molecular complexity in a single operation. |
| |
| Keywords: | acylation cyclization oxindole photoredox catalysis synthetic methods |
|
