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| 5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇的合成 | |
| 引用本文： | 李合平a,余鹏b,张洪杰b,刘宏民b. 5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇的合成[J]. 中国化学, 2008, 26(9): 1666-1668. DOI: 10.1002/cjoc.200890301 |
| 作者姓名： | 李合平a 余鹏b 张洪杰b 刘宏民b |
| 作者单位： | a 河南中医学院药学院，郑州，400008 ;b 郑州大学新药研究开发中心，郑州，450008 ; |
| 摘 要： | 以5-雄烯二醇为原料，用微生物转化的方法合成了两个重要的神经甾体5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇。所用菌种总枝毛霉为我们自己筛选，并首次应用于5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇的合成中。 |
| 关 键 词： | 生物转化 5-雄烯二醇 5-雄烯-3β 7α 17β-三醇 5-雄烯-3β 7β 17β-三醇 |
| 收稿时间： | 2008-01-11 |
| 修稿时间： | 2008-04-08 |
Synthesis of 5‐Androstene‐3β,7α,17β‐triol and 5‐Androstene‐3β,7β,17β‐triol |
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| He‐Ping LI,Peng YU,Hong‐Jie ZHANG,Hong‐Min LIU. Synthesis of 5‐Androstene‐3β,7α,17β‐triol and 5‐Androstene‐3β,7β,17β‐triol[J]. Chinese Journal of Chemistry, 2008, 26(9): 1666-1668. DOI: 10.1002/cjoc.200890301 | |
| Authors: | He‐Ping LI Peng YU Hong‐Jie ZHANG Hong‐Min LIU |
| Affiliation: | 1. School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan 450008, China;2. New Drug Research & Development Centrer, Zhengzhou University, Zhengzhou, Henan 450052, China;3. Tel.: 0086‐0371‐67767200;4. Fax: 0086‐0371‐67767200 |
| Abstract: | Two important neuroactive steroids 5‐androstene‐3β,7α,17β‐triol ( 6 ) and 5‐androstene‐3β,7β,17β‐triol ( 7 ) were prepared through a microbial transformation of 5‐androstene‐3β,17β‐diol, which was the first report for the synthesis of compounds 6 and 7 through a microbial transformation with Mucor racemosu isolated by ourselves. |
| Keywords: | biotransformation 5‐androstene‐3β,17β‐diol steroid 5‐androstene‐3β,7α,17β‐triol 5‐androstene‐3β,7β,17β‐triol |
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