Mass spectrometry detection of minor new meridianins from the antarctic colonial ascidians Aplidium falklandicum and Aplidium meridianum |
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| Authors: | Laura Núñez‐Pons Rosa María Nieto Conxita Avila Carlos Jiménez Jaime Rodríguez |
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| Affiliation: | 1. Department of Animal Biology (Invertebrates) & Biodiversity Research Institute (IrBio), Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain;2. Centro de Investigacions Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Facultade de Ciencias, Universidade da Coru?a, Galicia, Spain |
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| Abstract: | Taking into account the broad biological activities found in the meridianin indole alkaloids isolated to date, we have re‐examined the organic extracts of an Antarctic collection of the tunicates Aplidium meridianum and A. falklandicum (Chordata: Ascidiacea) by HPLC in conjunction with a high‐resolution mass spectrometer (HPLC‐MS). A new set of analogs of meridianins A–G has been detected, and their structures are proposed on the basis of the molecular formulae identified by LC‐HRMS analysis using a C18 column with a gradient of water/acetonitrile and an LTQ‐FT‐MS Orbitrap detector. Remarkably, dimers derived from meridianin A and from meridianin B or E were also detected. Our findings provide further evidence of the broad variability within the meridianin‐like derivatives of this highly bioactive alkaloid family. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | marine natural products Aplidium meridianum A. falklandicum indole alkaloids meridianins meridianin‐dimers LC‐MS FTMS‐Orbitrap |
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