| 1-(3-芳亚甲基氨基)丙基-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷金属络合物的合成及其抗肿瘤活性研究 |
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| 引用本文： | 丁齐柱,罗宣干,卓仁禧. 1-(3-芳亚甲基氨基)丙基-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷金属络合物的合成及其抗肿瘤活性研究[J]. 高等学校化学学报, 1989, 10(12): 1254 |
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| 作者姓名： | 丁齐柱 罗宣干 卓仁禧 |
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| 作者单位： | 武汉大学化学系 |
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| 摘 要： | 我们曾对1-亚甲基氨基烷基-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷的合成及其抗肿瘤活性作过研究,发现1-[3-(2-羟基苯亚甲基氨基)丙基]-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷和1-[3-(2,4-二羟基苯亚甲基氨基)丙基]-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷具有较好的抗肿瘤活性。已知亚甲胺类(Schiff碱)化合物与某些金属离子形成络合物后,能提高它们的抗肿瘤活性。为此,我们进一步研究了这两种亚甲胺衍生物的合成及其抗肿瘤活性。
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| 关 键 词： | 抗肿瘤活性 Schiff碱 金属络合物 2 8 9-三氧杂-5-氮杂-1-硅杂双环[3 3 3]十一烷 |
| 收稿时间： | 1988-05-14 |
Studies on the Synthesis and Antitumor Activity of 3-(Arylmethyleneamino)propylsilatrane-Metal Complexes |
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| Ding Qizhu,Luo Xuangan,Zhuo Renxi. Studies on the Synthesis and Antitumor Activity of 3-(Arylmethyleneamino)propylsilatrane-Metal Complexes[J]. Chemical Research In Chinese Universities, 1989, 10(12): 1254 |
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| Authors: | Ding Qizhu Luo Xuangan Zhuo Renxi |
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| Affiliation: | Department of Chemistry, Wuhan University, Wuhan |
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| Abstract: | Ten 3-(arylmethyleneamino)propylsilatrane-metal complexes were synthesized by the reaction of metal salt with 3- (2-hydroxybenzylideneamino) propylsilatrane or 3-(2, 4-dihydroxyben-zylideneamino)propylsilatrane in methanol.The structure of these new complexes were identified by 1H NMR, IRand elemental analysis.Animal screening data show that the inhibition ratio of bis-[N-(3-silatranylpropyl)-2-hydroxybenzylideneaminato] copper(Ⅱ) against Erlich ascites cancer in mice is 42.7%. |
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| Keywords: | Antitumor activity Schiff base Metal complex 2 8 9-Trioxa-5-aza-l-sila-bicyclo[3 3 3]-undecane |
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