Catalytic Enantioselective CH Functionalization of Alcohols by Redox‐Triggered Carbonyl Addition: Borrowing Hydrogen,Returning Carbon |
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| Authors: | John M. Ketcham Inji Shin T. Patrick Montgomery Prof. Michael J. Krische |
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| Affiliation: | University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station ‐ A5300, Austin, TX 78712‐1167 (USA) |
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| Abstract: | The use of alcohols and unsaturated reactants for the redox‐triggered generation of nucleophile–electrophile pairs represents a broad, new approach to carbonyl addition chemistry. Discrete redox manipulations that are often required for the generation of carbonyl electrophiles and premetalated carbon‐centered nucleophiles are thus avoided. Based on this concept, a broad, new family of enantioselective C? C coupling reactions that are catalyzed by iridium or ruthenium complexes have been developed, which are summarized in this Minireview. |
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| Keywords: | enantioselective catalysis iridium polyketide natural products ruthenium transfer hydrogenation |
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