Iron‐Catalyzed 1,2‐Addition of Perfluoroalkyl Iodides to Alkynes and Alkenes |
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| Authors: | Dr. Tao Xu Dr. Chi Wai Cheung Prof. Dr. Xile Hu |
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| Affiliation: | Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISCI‐LSCI, BCH 3305, 1015 Lausanne (Switzerland) http://lsci.epfl.ch |
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| Abstract: | Iron catalysis has been developed for the intermolecular 1,2‐addition of perfluoroalkyl iodides to alkynes and alkenes. The catalysis has a wide substrate scope and high functional‐group tolerance. A variety of perfluoroalkyl iodides including CF3I can be employed. The resulting perfluoroalkylated alkyl and alkenyl iodides can be further functionalized by cross‐coupling reactions. This methodology provides a straightforward and streamlined access to perfluoroalkylated organic molecules. |
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| Keywords: | alkyne cross‐coupling fluorine iron synthetic methods |
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