Accessing New Chemical Entities through Microfluidic Systems |
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| Authors: | Dr. Tiago Rodrigues Dr. Petra Schneider Prof. Dr. Gisbert Schneider |
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| Affiliation: | Eidgen?ssische Technische Hochschule (ETH) Zürich, Departement für Chemie und Angewandte Biowissenschaften, Vladimir‐Prelog‐Weg 4, 8093 Zürich (Switzerland) |
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| Abstract: | Flow systems have been successfully utilized for a wide variety of applications in chemical research and development, including the miniaturization of (bio)analytical methods and synthetic (bio)organic chemistry. Currently, we are witnessing the growing use of microfluidic technologies for the discovery of new chemical entities. As a consequence, chemical biology and molecular medicine research are being reshaped by this technique. In this Minireview we portray the state‐of‐the‐art, including the most recent advances in the application of microchip reactors as well as the micro‐ and mesoscale coil reactor‐assisted synthesis of bioactive small molecules, and forecast the potential future use of this promising technology. |
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| Keywords: | chemical biology drug discovery lab‐on‐a‐chip organic synthesis |
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