阳离子交换皂石黏土在基质辅助激光解吸电离飞行时间质谱分析中的应用

将一种人工合成的无机聚合物——蒙脱石皂石黏土（smectite，Sm）应用于基质辅助激光解吸电离飞行时间质谱分析（matrix-assisted laser desorption/ionization time of flight mass spectrometry, MALDI-TOF-MS），以检测糖类化合物。 将传统的有机基质2，4，6-三羟基苯乙酮（trihydroxyacetophenone, THAP）与阳离子交换后的皂石黏土混合制备成新型复合基质，应用于糖类化合物的检测。通过比较不同的制样方法，测定不同分子直径的糖类化合物，发现由于受复合基质晶面间距的限制，只有小分子糖类化合物能进入晶面间隙充分接触有机基质并被离子化，从而实现对小分子糖类化合物的选择性检测。

Cation-exchanged smectite layers for matrix-assisted laser desorption/ionization mass spectrometry analysis

Smectite, a synthetic inorganic polymer with a saponite structure, was subjected to matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) for the detection of saccharides. Typical organic matrix molecules 2,4,6-trihydroxyacetophenone (THAP) were intercalated into the layer spacing of cation-exchanged smectite and the complex was used as a new matrix for laser desorption/ionization mass spectrometry. Through the comparison of different sample preparation methods as well as the measurement of saccharides with disparate grain size, it is found that only saccharides of small analyte could enter the layer and bind to THAP can be ionized because of layer spacing limitations.