| 脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景 |
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| 引用本文： | 韩凝,明镇寰,朱睦元.脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景[J].浙江大学学报(理学版),2001,28(5):567-571. |
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| 作者姓名： | 韩凝 明镇寰 朱睦元 |
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| 作者单位： | 浙江大学生命科学学院 |
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| 摘 要： | ara-C,CNDAC等核苷类似物药物通过与DNA链的结合，抑制DNA合成，导致细胞死亡，从而发挥其肿瘤活性，它们的活化必须借助于脱氧胞苷激酶的磷酸化作用，本文介绍类药物的细胞毒性机制和药物抗性机制的研究进展，并对其发展前景进行了展望。
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| 关 键 词： | 核苷类似物 抗肿瘤药物 脱氧胞苷激酶 细胞毒性机制 药物抗性机制 |
| 文章编号： | 1008-9497(2001)05-0567-05 |
| 修稿时间： | 2000年12月27 |
Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase. |
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| HAN Ning,MING Zheng\|huan,ZHU Mu\|yuan.Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase.[J].Journal of Zhejiang University(Sciences Edition),2001,28(5):567-571. |
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| Authors: | HAN Ning MING Zheng\|huan ZHU Mu\|yuan |
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| Abstract: | The nucleoside analogue such as ara\|C and CNDAC exert their antitumor activities through incorporation into DNA strand, inhibiting DNA synthesis and causing the cell kill. In order to be active, they need to be phosphorylated by deoxycytidine kinase. This review discusses the cytotoxic action and resistant mechanism, and introduces some advances in the development of this kind of agents. |
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| Keywords: | nucleoside analogue antitumor agent/drug |
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