大鼠青春期同伴关系对青年期焦虑样和抑郁样行为的影响

探索大鼠青春期同伴关系对青年期焦虑样和抑郁样行为的影响. 将25只出生20d的清洁级雄性SD大鼠随机分成3组, 单笼组(n=8), 成双组(n=8), 群体组(n=9), 饲养40d后, 进行糖水偏好、高架迷宫和强迫游泳实验. 结果显示: 糖水偏好实验中, 3组大鼠的糖水消耗百分比无明显差异(P>0.05); 高架迷宫实验中, 成双组和群养组大鼠进入开放臂时间较单笼组明显减少(P< 0.01); 强迫游泳实验中, 单笼组大鼠不动时间较成双组和群养组明显延长(P<0.01). 表明青春期孤独环境大鼠容易产生抑郁样行为, 而同伴和群体饲养环境由于竞争压力容易产生焦虑样行为.

Effects of Adolescent Peer Relations on Anxiety-like and Depression-like Behaviors in Young-adult Rats

To explore the effects of adolescent peer relations on anxiety-like and depression-like behaviors in young-adult rats. 25 male Sprague-Dawley rats on postnatal day 20 are randomly divided into three groups. In the first group (n=8) rats are housed alone, in the second group (n=8) rats are reared in pairs, and in the third group (n=9) rats are divided into two cages, 4 in one cage, 5 in another one. After 40 days, the sucrose preference test, the elevated plus-maze test and the forced swimming test are taken and assessed in turn. In the sucrose preference test, there is no statistically significant difference among the three groups (P>0.05). In the elevated plus-maze test, the percentage of time on opened arm in both the paired and grouped rats reduces significantly compared with the lonely feed rats (P<0.01). In the forced swimming test, the lonely feed rats take more time with immobility compared with both the paired and grouped rats (P<0.01). The present data show that adolescent rats in the isolated environment are easier to produce depression-like behaviors, while housed with companions are easier to generate anxiety-like behaviors due to the peer competition