Antibacterial activities of polystyrene-block-poly(4-vinyl pyridine) and poly(styrene-random-4-vinyl pyridine) |
| |
Authors: | Eun Soo Park Hun Sik Kim Mal Nam Kim Jin San Yoon |
| |
Institution: | aDepartment of Polymer Science and Engineering, Inha University, Incheon 402-751, Republic of Korea bDepartment of Biology, Sangmyung University, Seoul 110-743, Republic of Korea |
| |
Abstract: | Styrene was polymerized in the presence of benzoyl peroxide (BPO) and 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) to yield polystyrene-TEMPO (PS-TEMPO) macroinitiator. The PS-TEMPO macroinitiator with different molecular weight was reacted with 4-vinyl pyridine (4-VP) to synthesize polystyrene-block-poly(4-vinyl pyridine) (PS-b-PVP), which was then quaternized with n-octyl iodide. Antibacterial activity of the quaternized copolymers was assessed against a gram negative bacterium (Pseudomonas aeruginosa) and a gram positive one (Staphylococcus aureus) by using the shake flask test method, and the results were compared with those of poly(styrene-random-4-vinyl pyridine) (P(ST-r--VP)). The quaternized copolymers inhibited greatly the growth of the bacteria, and PS-b-PVP was more active than P(ST-r-VP), which was ascribed to the fact that the content of quaternized 4-VP units on the surface of the particles of the former copolymer was higher than that corresponding to the latter one. |
| |
Keywords: | Copolymer Antibacterial activity Quaternized 4-vinyl pyridine n-Octyl iodide |
本文献已被 ScienceDirect 等数据库收录! |
|