Bacterial acyltransferases as an alternative for lipase-catalyzed acylation for the production of oleochemicals and fuels |
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Authors: | Stöveken Tim Steinbüchel Alexander |
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Institution: | Institut für Molekulare Mikrobiologie und Biotechnologie, Westf?lische Wilhelms‐Universit?t Münster, Corrensstr. 3, 48149 Münster, Germany, Fax: (+49)?251‐833‐8388 http://mibi1.uni‐muenster.de/ |
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Abstract: | Bacterial acyltransferases are a new class of enzymes, and the first member was identified as WS/DGAT in Acinetobacter baylyi ADP1. Their unspecificity have been used in several biotechnological applications for lipid modification, a field that has been dominated by the use of lipases. Examples are the biosynthesis of jojoba-like wax esters and fatty-acid ethyl esters. In addition, these enzymes are also capable of synthesizing acylthioesters. Acyloxoesters and acylthioesters can thus be produced in vivo by whole-cell fermentations rather than in vitro in an enzyme reactor. In this Minireview, we focus on the biotechnological utilization of acyltransferases for the production of modified lipids from renewable resources. |
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Keywords: | acyltransferases biosyntheses biotechnology enzymes lipids |
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