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Surface Plasmon Resonance Microscopy: From Single‐Molecule Sensing to Single‐Cell Imaging
Authors:Xiao‐Li Zhou  Yunze Yang  Shaopeng Wang  Xian‐Wei Liu
Abstract:Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single‐molecule sensing to single‐cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.
Keywords:binding kinetics  label-free methods  single-cell imaging  sensors  surface plasmon  resonance
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