Photocatalytic Generation of N‐Centered Hydrazonyl Radicals: A Strategy for Hydroamination of β,γ‐Unsaturated Hydrazones |
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| Authors: | Xiao‐Qiang Hu Prof?Dr Jia‐Rong Chen Qiang Wei Feng‐Lei Liu Qiao‐Hui Deng Prof?Dr André M Beauchemin Prof?Dr Wen‐Jing Xiao |
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| Institution: | 1. CCNU–uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079 (China) http://chem‐xiao.ccnu.edu.cn/;2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin (China);3. Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, ON, K1N 6N5 (Canada) |
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| Abstract: | A visible‐light photocatalytic generation of N‐centered hydrazonyl radicals has been accomplished for the first time. This approach allows efficient intramolecular addition of hydrazonyl radical to terminal alkenes, thus providing hydroamination and oxyamination products in good yields. Importantly, the protocol involves deprotonation of an N? H bond and photocatalytic oxidation to an N‐centered radical, thus obviating the need to prepare photolabile amine precursors or the stoichiometric use of oxidizing reagents. |
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| Keywords: | heterocycles hydrazones photocatalysis radicals ruthenium |
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