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Oxygenase‐Catalyzed Desymmetrization of N,N‐Dialkyl‐piperidine‐4‐carboxylic Acids |
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| Authors: | Anna M Rydzik Ivanhoe K H Leung Grazyna T Kochan Michael A McDonough Timothy D W Claridge Prof Christopher J Schofield |
| Institution: | 1. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA (UK);2. Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosvelt Drive, Headington OX3 7DQ, United Kingdom;3. Current address: Navarrabiomed‐Fundacion Miguel Servet, C/Irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain. |
| Abstract: | γ‐Butyrobetaine hydroxylase (BBOX) is a 2‐oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N‐dialkyl piperidine‐4‐carboxylates to give products with two or three stereogenic centers. |
| Keywords: | biocatalysis γ ‐butyrobetaine hydroxylase C– H activation desymmetrisation oxygenases |