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Dual‐Function Probe to Detect Protease Activity for Fluorescence Measurement and 19F MRI |
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| Authors: | Shin Mizukami Dr Rika Takikawa Fuminori Sugihara Masahiro Shirakawa Prof Kazuya Kikuchi Prof |
| Institution: | 1. Graduate School of Engineering, Osaka University, Osaka 565‐0871 (Japan), Fax: (+81) 6‐6879‐7924;2. International Graduate School of Arts and Sciences, Yokohama City University, Kanagawa 230‐0045 (Japan), Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Saitama 351‐0198 (Japan), http://www‐molpro.mls.eng.osaka‐u.ac.jp/;3. Graduate School of Engineering, Kyoto University, Kyoto 615‐8510 (Japan), CREST, Science and Technology Corporation, Saitama 332‐0012 (Japan) |
| Abstract: | Dynamic duo : Magnetic resonance imaging (MRI) can visualize deep regions of living bodies, whereas fluorescence measurement offers excellent sensitivity. These methods thus offer signal enhancement potential for detecting enzyme activities. A dual‐mode off/on probe to detect caspase‐3 activity by fluorescence and 19F MRI is presented.  |
| Keywords: | fluorescence magnetic resonance imaging molecular imaging multimodal probe proteases |