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Insights into the Crystallization and Structural Evolution of Glycine Dihydrate by In Situ Solid‐State NMR Spectroscopy |
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| Authors: | Dr Paolo Cerreia?Vioglio Dr Giulia Mollica Marie Juramy Dr Colan E Hughes Dr P Andrew Williams Dr Fabio Ziarelli Prof Stéphane Viel Dr Pierre Thureau Prof Kenneth D M Harris |
| Institution: | 1. Aix Marseille Univ, CNRS, ICR, Marseille, France;2. School of Chemistry, Cardiff University, Cardiff, Wales, UK;3. Aix Marseille Univ, CNRS, Centrale Marseille, FSCM FR1739, Marseille, France;4. Institut Universitaire de France, Paris, France |
| Abstract: | In situ solid‐state NMR spectroscopy is exploited to monitor the structural evolution of a glycine/water glass phase formed on flash cooling an aqueous solution of glycine, with a range of modern solid‐state NMR methods applied to elucidate structural properties of the solid phases present. The glycine/water glass is shown to crystallize into an intermediate phase, which then transforms to the β polymorph of glycine. Our in situ NMR results fully corroborate the identity of the intermediate crystalline phase as glycine dihydrate, which was first proposed only very recently. |
| Keywords: | crystallization glycine polymorphism solid-state NMR spectroscopy structural transformation |