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Electrochemical C−H/N−H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles |
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| Authors: | Zhong‐Wei Hou Zhong‐Yi Mao Huai‐Bo Zhao Yared Yohannes Melcamu Prof?Dr Xin Lu Dr Jinshuai Song Prof?Dr Hai‐Chao Xu |
| Institution: | 1. http://chem.xmu.edu.cn/groupweb/hcxu/index.asp;2. Collaborative Innovation Center of Chemistry for Energy Material, State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province and, Department of Chemistry, Xiamen University, Xiamen, P.R. China;3. Fujian Institute of Research on Structure of Matter, Chinese Academy of Sciences, Fuzhou, P.R. China |
| Abstract: | Indoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble‐metal‐ and oxidant‐free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles. |
| Keywords: | electrochemistry heterocycles indoles radicals redox chemistry |