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Radical Cyclization/ipso‐1,4‐Aryl Migration Cascade: Asymmetric Synthesis of 3,3‐Difluoro‐2‐propanoylbicyclo[3.3.0]octanes |
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| Authors: | Watcharaporn Thaharn Dr Darunee Soorukram Dr Chutima Kuhakarn Dr Patoomratana Tuchinda Prof?Dr Vichai Reutrakul Prof?Dr Manat Pohmakotr |
| Institution: | Center of Excellence for Innovation in Chemistry (PERCH‐CIC) and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400 (Thailand) |
| Abstract: | A novel method for the asymmetric synthesis of 3,3‐difluoro‐2‐propanoylbicyclo‐3.3.0]octanes involves an unprecedented intramolecular radical cyclization/ipso‐1,4‐aryl migration cascade. |
| Keywords: | cyclization fluorine radical reactions reaction mechanism synthetic methods |